Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Nucleophosmin / ribosome biogenesis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| NPM1 | participates_in | gene | 0.38 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Nucleolar Stress Response Normalization | 0.378 | neurodegeneration | RNA binding protein dysregulation across |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.490
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| DNA Damage Repair Deficiency Validation Study in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| NPM1 inhibits tumoral antigen presentation to promote immune evasion and tumor p [PMID:39402629] | Wang X, Chai Y, Quan Y, Wang J, Song J, | J Hematol Oncol | 2024 | 1 |
| Significance of NPM1 Gene Mutations in AML. [PMID:34576201] | Hindley A, Catherwood MA, McMullin MF, M | Int J Mol Sci | 2021 | 1 |
| NPM1-mutated acute myeloid leukemia: from bench to bedside. [PMID:32609823] | Falini B, Brunetti L, Sportoletti P, Mar | Blood | 2020 | 1 |
| Insights into the regulation of neuronal viability by nucleophosmin/B23. [PMID:25908633] | Pfister JA, D'Mello SR | Exp Biol Med (Maywood) | 2015 | 1 |
| Functions of the histone chaperone nucleolin in diseases. [PMID:17484127] | Storck S, Shukla M, Dimitrov S, Bouvet P | Subcell Biochem | 2007 | 1 |
| Long-term outcomes in FLT3-mutated acute myeloid leukemia after frontline hypome [PMID:41035402] | Short NJ, Loghavi S, Yilmaz M, Karrar O, | Haematologica | 2026 | 0 |
| A Unified Model: Chromatin-Bound Multicomponent Condensates. [PMID:41481253] | Lau BK, Haarer EL, Ahn JH, Wang GG | Cancer Res | 2026 | 0 |
| Discovery and optimization of Menin-MLL inhibitors targeting acute myeloid leuke [PMID:41666760] | Xiao Q, Wang Y, Shen Z, Mo J, Li C et al | Eur J Med Chem | 2026 | 0 |
| Targeting the Menin-KMT2A Axis in Acute Leukemia: From Epigenetic Dependency to [PMID:41923577] | Bruzzese A, Vigna E, Martino EA, Caserta | Eur J Haematol | 2026 | 0 |
| Response to Comment on: "Prognostic implications of myelodysplasia-related gene [PMID:41924903] | Chang YS, Hou HA | Haematologica | 2026 | 0 |
| Quizartinib and omacetaxine mepesuccinate combination therapy in FLT3-ITD AML: a [PMID:41942459] | Zheng LC, Wong KKW, Lam SSY, Leung GMK, | Nat Commun | 2026 | 0 |
| CPX-351 (Liposomal Cytarabine and Daunorubicin) versus venetoclax plus hypomethy [PMID:41942467] | Fathima S, Rokach L, Ghosoun N, Rezasolt | Blood Cancer J | 2026 | 0 |
| Fibrillarin: bridging ribosome biogenesis and apoptosis in cellular stress and d [PMID:41518572] | ["Zhang Z", "Zhang M", "Cao Z", "Zhao H" | Apoptosis : an international j | 2026 | 0 |
| Probing condensate microenvironments with a micropeptide killswitch. [PMID:40468084] | Zhang Y, Stöppelkamp I, Fernandez-Pernas | Nature | 2025 | 0 |
| Functions of the native NPM1 protein and its leukemic mutant. [PMID:39690184] | Falini B, Sorcini D, Perriello VM, Sport | Leukemia | 2025 | 0 |
| Spatial resolution of cellular senescence dynamics in human colorectal liver met [PMID:37157887] | ["Garbarino O", "Lambroia L", "Basso G", | Aging cell | 2023 | 0 |
| Doxorubicin induces an alarmin-like TLR4-dependent autocrine/paracrine action of [PMID:34134693] | ["Beji S", "D'Agostino M", "Gambini E", | BMC biology | 2021 | 0 |
| The nucleolus functions as a phase-separated protein quality control compartment [PMID:31296649] | Frottin F, Schueder F, Tiwary S, Gupta R | Science (New York, N.Y.) | 2019 | 0 |
| Small nucleoli are a cellular hallmark of longevity. [PMID:28853436] | ["Tiku V", "Jain C", "Raz Y", "Nakamura | Nature communications | 2017 | 0 |
| Repression of rRNA transcription by PARIS contributes to Parkinson's disease. [PMID:25315684] | ["Kang H", "Shin J"] | Neurobiology of disease | 2015 | 0 |